Pollution and High Cholesterol are Deadly Cocktail

Pollution and High Cholesterol are Deadly Cocktail

(July 26, 2007) Although diet, smoking and other factors contribute to the risk of cardiovascular disease — the leading cause of death in the Western world — scientists have long believed that air pollution, particularly tiny pieces of soot from trucks and factories, plays a major role, too.

For years, scientists around the world have reported that on days when fine-particle pollution increases, deaths from lung diseases, heart attacks and strokes rise substantially. Riverside County and the San Gabriel Valley have among the worst fine-particle pollution in the nation.

New research done by UCLA scientist suggests that people with high cholesterol are especially vulnerable to heart disease when they are exposed to diesel exhaust and other ultra-fine particles that are common pollutants in urban air.

Microscopic particles in diesel exhaust combine with cholesterol to activate genes that trigger hardening of the arteries.

“Their combination creates a dangerous synergy that wreaks cardiovascular havoc far beyond what’s caused by the diesel or cholesterol alone,” said Dr. André Nel, chief of nanomedicine at the David Geffen School of Medicine at UCLA and a researcher at UCLA’s California NanoSystems Institute.

The scientists say their study, conducted on human cells as well as on mice, is the first to explain how particulates in the air activate genes that can cause heart attacks or strokes.

The researchers exposed human blood cells to a combination of diesel particles and oxidized fats, then extracted their DNA. Working together, the particles and fats switched on genes that cause inflammation of blood vessels, which leads to clogged arteries, or atherosclerosis.

The scientists reported that diesel particles may enter the body’s circulatory system from the lungs, and then react with fats in the arteries to alter how genes are activated, triggering inflammation that causes heart disease.

Other research has shown similar inflammatory damage in lungs exposed to fine particles. Diesel exhaust has also been linked to lung cancer, asthma attacks and DNA damage.

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New Year’s Day is the first day of the new year. On the modern Gregorian calendar, it is celebrated on January 1, as it was also in ancient Rome (though other dates were also used in Rome). In all countries using the Gregorian calendar as their main calendar, except for Israel, it is a public holiday,^{[citation needed]} often celebrated with fireworks at the stroke of midnight as the new year starts. January 1 on the Julian calendar corresponds to January 14 on the Gregorian calendar, and it is on that date that followers of some of the Eastern Orthodox churches celebrate the New Year.

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New Study Renews Concerns of Cancer Risk with Statin Drugs

New Study Renews Concerns of Cancer Risk with Statin Drugs

(August 8, 2007) U.S. researchers reported renewed concerns that patients who took statin drugs to lower their cholesterol had a slightly higher risk of cancer. Statin drugs can also damage the liver and muscles.

The researchers found one extra case of cancer per 1,000 patients with the lowest levels of LDL — low density lipoprotein or so-called bad cholesterol — when compared to patients with higher LDL levels.

Dr. Richard Karas of Tufts University School of Medicine in Boston and colleagues did not look directly at patients for their study, published in the Journal of the American College of Cardiology.

They did what is known as a meta-analysis, looking at the records of 41,173 patients in 23 different trials of statins.

“The demonstrated benefits of statins in lowering the risk of heart disease remain clear; however, certain aspects of lowering LDL with statins remain controversial and merit further research,” Karas said in a statement.

Karas and colleagues examined the records of patients treated with popular statins, including Pfizer Inc.’s Lipitor and Merck & Co. Inc.’s Zocor, now off patent.

Dr. Peter Verdegem, Chief Scientist of Unicity International stated, “It has been widely known and accepted that statin therapy to lower cholesterol has serious side effects, such as muscle problems, liver damage and rhabdomyolisis. Also, it has been suspected that high statin therapy may be related to certain forms of cancer.”

The meta-analysis strengthens the arguments for this assumption.

Statin drugs contain non-natural chemical components that disrupt biological mechanisms in our body. Since our body is a complex system such disruptions may result in imbalances causing the side effects.

“Bios Life contains a blend of nutrients that are a natural part of our diet, therefore, Bios Life does not have the side effects associated with statin drugs. In stead it brings cholesterol levels to a healthy balance by providing our body with nutrients that are lacking from our food. Our body knows how to get cholesterol at healthy levels, provided we give it what it needs with Bios Life,” observed Dr. Verdegem.